Asociación del polimorfismo -174 G>C del gen IL-6 en pacientes con periodontitis Estadio II grado B
DOI:
https://doi.org/10.32776/revbiomed.v32i2.857Abstract
Antecedentes. Entre los factores de riesgo para periodontitis están descritos los genéticos, siendo la interleucina 6 (IL-6) una citocina implicada en el proceso inflamatorio y destrucción periodontal. Los polimorfismos en el gen IL-6 pueden explicar el riesgo de padecer la enfermedad en ciertas poblaciones.
Objetivo. Determinar la asociación del polimorfismo g.-174GIL-6 con la periodontitis Estadio II grado B.
Material y métodos. Estudio descriptivo, transversal, prospectivo y de casos y controles. Se analizaron las frecuencias genotípicas y alélicas de g.-174G
Resultados. Se determinaron las frecuencias genotípicas para el polimorfismo g.-174 G
Conclusión. No se observó asociación entre el polimorfismo g.-174 G/C y la periodontitis Estadio II grado B. Asimismo, se ha reportado una baja frecuencia del genotipo homocigoto mutado CC, el cual se encontró en el 2% de los controles y ausente en los casos estudiados.
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