miRNA Biomarkers?: Insights in neurodegenerative diseases

Authors

DOI:

https://doi.org/10.32776/revbiomed.v37.i2.1378

Keywords:

Neurodegeneratives diseases, Transcriptome, mRNA

Abstract

microRNAs play a key role in epigenetic and post-transcriptional mechanisms, developing mechanisms that allow us to understand the transcriptomics of brain function; this is an incentive to elucidate the pathogenesis of neurodegenerative diseases, particularly Alzheimer's and Parkinson's diseases, which have a higher incidence; currently, the characterization of miRNAs in the prodromal phase opens new avenues that allow them to be used as promising biomarkers, given their intricate role in various signaling pathways.

Author Biography

  • Paloma del Consuelo Montoya Zamora, sin adscripción institucional
    Docente de pregrado en asignaturas relacionadas al área químico biológicas 2016-2022 en instituciones de educaciòn pùblica del estado de Durango

References

1. Kay MA. Ruvkun and Ambros recognized for miRNAs. Mol Ther Nucleic Acids. 2024 Nov 20;35(4):102379. doi: 10.1016/j.omtn.2024.102379. PMID: 39640011; PMCID: PMC11617852.

2. Ma YM, Zhao L. Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases.

Behav Neurol. 2023 Nov 23;2023:8537296. doi: 10.1155/2023/8537296. PMID: 38058356; PMCID:

PMC10697780.

3. Alkhazaali-Ali Z, Sahab-Negah S, Boroumand AR, Tavakol-Afshari J. MicroRNA (miRNA) as a biomarker for diagnosis, prognosis, and therapeutics molecules in neurodegenerative disease. Biomed Pharmacother. 2024 Aug;177:116899. doi: 10.1016/j.biopha.2024.116899. Epub 2024 Jun 17. PMID: 38889636.

4. Sun E, Motolani A, Campos L, Lu T. The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics

of Alzheimer's Disease. Int J Mol Sci. 2022 Aug 11;23(16):8972. doi: 10.3390/ijms23168972. PMID: 36012242; PMCID: PMC9408758.

5. Hong H, Wang Y, Menard M, Buckley JA, Zhou L, Volpicelli-Daley L, Standaert DG, Qin H, Benveniste

EN. Suppression of the JAK/STAT pathway inhibits neuroinflammation in the line 61-PFF mouse model of Parkinson's disease. J Neuroinflammation. 2024 Sep 1;21(1):216. doi: 10.1186/s12974-024-03210-8. PMID: 39218899; PMCID: PMC11368013

Published

2026-05-01

Issue

Section

Editorial

How to Cite

“MiRNA Biomarkers?: Insights in Neurodegenerative Diseases”. Biomedical Journal, vol. 37, no. 2, May 2026, https://doi.org/10.32776/revbiomed.v37.i2.1378.