Adenovirus Humano Tipo 36 (Ad36) se relaciona con un mejor perfil lipídico en niños Mexicanos pero no con obesidad
Resumen
Introducción. La obesidad y su comorbilidad son de las principales causas de muerte en México, es una enfermedad multifactorial, en la que se ha visto además la participación de un agente infeccioso. Ad36 se ha asociado con obesidad, pero paradójicamente también con niveles más bajos de glucosa, colesterol y triglicéridos, sin embargo, existe controversia en diferentes poblaciones. Objetivo. Evaluar la asociación de anticuerpos antiAd36 con variables antropométricas y bioquímicas. Material y métodos. Estudio transversal en 299 niños mexicanos mestizos en edad escolar (6 a 12 años). Se obtuvieron mediciones antropométricas de altura, peso corporal, circunferencia de la cintura, grosor del pliegue cutáneo del tríceps, se calculó índice de masa corporal (IMC) y relación cintura/ altura. Las variables bioquímicas incluyeron niveles séricos de glucosa, triglicéridos, colesterol total, lipoproteínas de alta densidad y lipoproteínas de baja densidad. Se utilizó un ensayo inmunoabsorbente ligado a enzimas (ELISA) para determinar los anticuerpos contra Ad36 en las muestras de suero. Resultados. Los anticuerpos anti-Ad36 se asociaron con niveles más bajos de colesterol sérico total (β = -0.133, p = 0.021) y LDL (β = -0.166, p = 0.004), y con niveles más altos de HDL (β = 0.120, p = 0.037), pero no con obesidad. Conclusión. En resumen, la exposición previa a Ad36 se asoció con un mejor perfil lipídico en niños mexicanos, independientemente de la obesidad
Background. Obesity and its comorbidities are one of the main causes of death in Mexico; it is a multifactorial disease, in which the participation of an infectious agent has been evaluated. Ad36 is associated with obesity, but paradoxically also with lower levels of glucose, cholesterol and triglycerides; however, there is controversy in different populations. Objective. To evaluate the association of antibodies against Ad36 with anthropometric and biochemical variables. Material and Methods. Cross-sectional study in 299 Mexican-mestizo children of elementary schools (6-12 years old). Anthropometric measurements of height, body weight, waist circumference, thickness of the triceps skin fold were obtained; body mass index (BMI) and waist / height ratio were calculated. Biochemical variables included serum glucose, triglycerides, total cholesterol, high-density lipoproteins, and low-density lipoproteins. An enzyme-linked immunosorbent assay (ELISA) was used to determine antibodies against Ad36 in serum samples. Results. Anti-Ad36 antibodies were associated with lower levels of total serum cholesterol (β = -0.133, p = 0.021) and LDL (β = -0.166, p = 0.004), and with higher levels of HDL (β = 0.120, p = 0.037), but not with obesity. Conclusion. Previous exposure to Ad36 was associated with a better lipid profile in Mexican children, regardless of obesity
Referencias
Instituto Nacional de Estadística Geografía e Informática. Características de las defunciones registradasen México durante 2018 [Internet]. 2019 [cited 2020 Jan 9]. Available from: https://www.inegi.org.mx/app/tabulados/pxwebv2/pxweb/es/Mortalidad/Mortalidad/Mortalidad_04.px/table/tableViewLayout2/
McAllister EJ, Dhurandhar N V, Keith SW, Aronne LJ, Barger J, Baskin M, et al. Ten Putative Contributors to the Obesity Epidemic. Crit Rev Food Sci Nutr [Internet]. 2009 Dec 10;49(10):868–913. Available from: https://www.tandfonline.com/doi/full/10.1080/10408390903372599
Hainer V, Zamrazilová H, Kunešová M, Bendlová B, Aldhoon-Hainerová I. Obesity and Infection: Reciprocal Causality. Physiol Res [Internet]. 2015 [cited 2019 Aug 26];64:105–19. Available from: www.biomed.cas.cz/physiolres
Akheruzzaman M, Hegde V, Dhurandhar N V. Twenty-five years of research about adipogenic adenoviruses: A systematic review. Obesity Reviews. 2019. doi: 10.1111/obr.12808
Pasarica M, Shin AC, Yu M, Ou Yang H-M, Rathod M, Jen K-LC, et al. Human adenovirus 36 induces adiposity, increases insulin sensitivity, and alters hypothalamic monoamines in rats. Obesity (Silver Spring) [Internet]. 2006 Nov;14(11):1905–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17135605. doi: 10.1038/oby.2006.222.
Dhurandhar N V, Whigham LD, Abbott DH, Schultz-darken NJ, Israel BA, Bradley SM, et al. Human Adenovirus Ad-36 Promotes Weight Gain in Male Rhesus and Marmoset Monkeys. J Nutr. 2002;132(May):3155–60. doi: 10.1093/jn/131.10.3155
Dhurandhar N V, Israel B a, Kolesar JM, Mayhew G, Cook ME, Atkinson RL. Transmissibility of adenovirus-induced adiposity in a chicken model. Int J Obes Relat Metab Disord [Internet]. 2001 Jul;25(7):990–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11443497. doi: 10.1038/sj.ijo.0801668.
Atkinson RL, Dhurandhar N V, Allison DB, Bowen RL, Israel B a, Albu JB, et al. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int J Obes (Lond) [Internet]. 2005 Mar [cited 2012 Oct 24];29(3):281–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15611785. doi: 10.1038/sj.ijo.0802830.
Atkinson RL, Lee I, Shin H-J, He J. Human adenovirus-36 antibody status is associated with obesity in children. Int J Pediatr Obes [Internet]. 2010 Apr [cited 2014 Apr 9];5(2):157–60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19593728. doi: 10.3109/17477160903111789.
Na H-N, Hong Y-M, Kim J, Kim H-K, Jo I, Nam J-H. Association between human adenovirus-36 and lipid disorders in Korean schoolchildren. Int J Obes (Lond) [Internet]. 2010 Jan [cited 2014 Apr 9];34(1):89–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19823186. doi: 10.1038/ijo.2009.207
LaVoy EC, Arlinghaus KR, Rooney B V., Gupta P, Atkinson R, Johnston CA. High adenovirus 36 seroprevalence among a population of Hispanic American youth. Int J Adolesc Med Health. 2018 Nov 29:/j/ijamh.ahead-of-print/ijamh-2018-0110/ijamh-2018-0110.xml. doi: 10.1515/ijamh-2018-0110
Lin W, Dubuisson O, Rubicz R et al. Long Term Changes in Adiposity and Glycemic Control Are Associated With Past Adenovirus Infection. Vol. 36, Diabetes Care. DIABETES CARE; 2013. p. 701–7.
Sapunar J, Fonseca L, Molina V, Ortiz E, Barra MI, Reimer C, et al. Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects. Int J Obes [Internet]. 2019; Available from: https://doi.org/10.1038/s41366-019-0321-4
Parra-Rojas I, Del Moral-Hernández O, Salgado-Bernabé AB, Guzmán-Guzmán IP, Salgado-Goytia L, Muñoz-Valle JF. Adenovirus-36 seropositivity and its relation with obesity and metabolic profile in children. Int J Endocrinol. 2013;2013. doi: 10.1155/2013/463194.
Leyva Barrera IM, Solís Pérez E, Torres López E. Adenovirus-36, Obesidad y alteraciones clínico metabólicas e escolares del estado de Nuevo León. Universidad Autónoma de Nuevo León; 2016. http://eprints.uanl.mx/19253/
Torres-González E de J, Zamarripa-Jáuregui RG, Carrillo-Martínez JM, Guerrero-Romero F, Martínez-Aguilar G. Prevalencia de sobrepeso y obesidad en niños escolares. Gac Med Mex. 2020;156(3):182–6. doi: 10.24875/GMM.M20000390
De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school children and adolescents [Internet]. 2007 [cited 2014 Aug 5]. Available from: http://www.who.int/growthref/growthref_who_bull.pdf?ua=1. doi: 10.2471/blt.07.043497.
Browning LM, Hsieh SD, Ashwell M. A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0·5 could be a suitable global boundary value. Nutr Res Rev [Internet]. 2010;23(02):247–69. Available from: http://www.journals.cambridge.org/abstract_S0954422410000144
Shamah-Levy T, Villalpando-Hernández S R-DJ. Resultados de Nutrición de la ENSANUT 2006. Cuernavaca, México; 2007. https://www.insp.mx/produccion-editorial/publicaciones-anteriores-2010/661-encuesta-nacional-de-salud-y-nutricion-2006-546.html
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499–502. PMID: 4337382
Zimmet P, Alberti G, Kaufman F, Tajima N, Silink M, Arslanian S, et al. The metabolic syndrome in children and adolescents–an IDF consensus report. Diabetes Voice [Internet]. 2007;52(4):29–32. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-5448.2007.00271.x/full
Rivera Dommarco J, Shamah Levy T, Villalpando Hernández S, González de Cossío T, Hernández Prado B SJ. Encuesta Nacional de Nutrición 1999.Estado Nutricio de niños y mujeres de México. Cuernavaca, Morelos; 2001. https://www.medigraphic.com/pdfs/salpubmex/sal-2003/sals034m.pdf
Cámara de Diputados. REGLAMENTO DE LA LEY GENERAL DE SALUD EN MATERIA DE INVESTIGACION PARA LA SALUD [Internet]. México, México; 2014 [cited 2020 Aug 4]. Available from: http://www.diputados.gob.mx/LeyesBiblio/regley/Reg_LGS_MIS.pdf
Flores M, Macías N, Rivera M, Barquera S, Hernández L, García-Guerra A, et al. Energy and nutrient intake among Mexican school-aged children, Mexican National Health and Nutrition Survey 2006. Salud Publica Mex [Internet]. 2009 Jan;51 Suppl 4:S540-50. Available from: https://ensanut.insp.mx/encuestas/ensanut2006/doctos/analiticos/EnergyNutrientEsc.pdf
Dhurandhar EJ, Krishnapuram R, Hegde V, Dubuisson O, Tao R, Dong XC, et al. E4orf1 Improves Lipid and Glucose Metabolism in Hepatocytes: A Template to Improve Steatosis & Hyperglycemia. PLoS One [Internet]. 2012 Jan [cited 2014 Jun 4];7(10):e47813. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3479113&tool=pmcentrez&rendertype=abstract. doi: 10.1371/journal.pone.0047813
Na H-N, Kim J, Lee HS, Shim KW, Kimm H, Jee SH, et al. Association of human adenovirus-36 in overweight Korean adults. Int J Obes (Lond) [Internet]. 2012 Feb [cited 2014 Apr 9];36(2):281–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21587203. doi: 10.1038/ijo.2011.102
Vander Wal J, Huelsing J, Dubuisson O, Dhurandhar N. An observational study of the association between adenovirus 36 antibody status and weight loss among youth. Obes Facts. 2013;6(3):269-78. doi: 10.1159/000353109
Trovato GM, Martines GF, Trovato FM, Pirri C, Pace P, Garozzo A, et al. Adenovirus-36 seropositivity enhances effects of nutritional intervention on obesity, bright liver, and insulin resistance. Dig Dis Sci [Internet]. 2012 Feb [cited 2012 Oct 24];57(2):535–44. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21953137. doi: 10.1007/s10620-011-1903-8.
Aldhoon-Hainerová I, Zamrazilová H, Atkinson RL, Dušátková L, Sedláčková B, Hlavatý P, et al. Clinical and laboratory characteristics of 1179 Czech adolescents evaluated for antibodies to human adenovirus 36. Int J Obes [Internet]. 2014 [cited 2019 May 24];38(2):285–91. Available from: www.nature.com/ijo. doi: 10.1038/ijo.2013.72
Cakmakliogullari EK, Sanlidag T, Ersoy B, Akcali S, Var A, Cicek C. Are human adenovirus-5 and 36 associated with obesity in children? J Investig Med [Internet]. 2014;62(5):821–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24987976. doi: 10.2310/JIM.0000000000000084
Kocazeybek B, Dinc HO, Ergin S, Saribas S, Ozcabi BT, Cizmecigil U, et al. Evaluation of Adenovirus-36 (Ad-36) antibody seropositivity and adipokine levels in obese children. Microb Pathog. 2017;108:27–31. doi: 10.1016/j.micpath.2017.04.034.
Ergin S, Altan E, Pilanci O, Sirekbasan S, Cortuk O, Cizmecigil U, et al. The role of adenovirus 36 as a risk factor in obesity: The first clinical study made in the fatty tissues of adults in Turkey. Microb Pathog [Internet]. 2015 [cited 2019 May 24];80(1):57–62. Available from: http://dx.doi.org/10.1016/j.micpath.2015.02.008
Shang Q, Wang H, Song Y, Wei L, Lavebratt C, Zhang F, et al. Serological data analyses show that adenovirus 36 infection is associated with obesity: A meta-analysis involving 5739 subjects. Obesity. 2014;22(3):895–900. doi: 10.1002/oby.20533
Xu MY, Cao B, Wang DF, Guo JH, Chen KL, Shi M, et al. Human adenovirus 36 infection increased the risk of obesity: A meta-Analysis update. Medicine (Baltimore). 2015 Dec;94(51):e2357. doi: 10.1097/MD.0000000000002357
Broderick M, Hansen C, Irvine M, Metzgar D, Campbell C, Baker C, et al. Adenovirus 36 seropositivity is strongly associated with race and gender, but not obesity, among US military personnel. Int J Obes. 2010;34:302–308. doi: 10.1038/ijo.2009.224.
Gutiérrez J., Rivera-Dommarco J, Shamah-Levy T, Villalpando-Hernández S, Franco A, Cuevas-Nasu L, et al. ENSANUT2012ResultadosNacionales. Cuernavaca, Morelos: Insituto Nacional de Salud Pública; 2012. http://ensanut.insp.mx/informes/ENSANUT2012ResultadosNacionales.pdf
Shamah-Levi T, Cuevas-Nasu L, Dommarco-Rivera J, Hernandez-Avila M. Encuesta Nacional de Salud y Nutrición de Medio Camino 2016. (ENSANUT MC 2016). Inst Nac Salud Pública [Internet]. 2016;2016(Ensanut):151. Available from: http://promocion.salud.gob.mx/dgps/descargas1/doctos_2016/ensanut_mc_2016-310oct.pdf
Vangipuram SD, Yu M, Tian J, Stanhope KL, Pasarica M, Havel PJ, et al. Adipogenic human adenovirus-36 reduces leptin expression and secretion and increases glucose uptake by fat cells. Int J Obes [Internet]. 2007 Jan [cited 2012 Oct 24];31(1):87–96. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16703005. doi: 10.1038/sj.ijo.0803366
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