Síndrome de Abstinencia Alcohólica: Resultado del estrés oxidativo y desequilibrio neuronal. Estado del arte
Resumen
El alcoholismo constituye una enfermedad crónica que conlleva a afectaciones conductuales que se prolongan durante la abstinencia. El consumo de etanol incrementa la acumulación de Acetaldehído y Especies Reactivas de Oxígeno provocando daño a nivel cerebral. Dos importantes neurotransmisores involucrados en el daño neuronal son el Ácido γ-Amino butírico (GABA,) un neurotransmisor inhibitorio y el glutamato el más importante neurotransmisor excitatorio, las afectaciones del receptor GABAérgico contribuyen a la tolerancia y dependencia al etanol y síntomas de hiperexcitabilidad en la abstinencia mientras que las afectaciones del receptor NMDA glutamatérgico contribuyen a la tolerancia y dependencia al etanol así como al establecimiento de los síntomas de abstinencia. Las afectaciones en el metabolismo del Etanol desencadenan alteraciones conductuales ya que la disfunción de la enzima Acetaldehído deshidrogenasa provoca acumulación a nivel cerebral de Acetaldehído responsable en gran medida del daño cerebral ocasionado durante el alcoholismo. En el presente trabajo se revisa de forma sistemática y organizada por temáticas, en orden lógico y partiendo de conceptos básicos, la literatura experimental existente en bases de datos como PubMed y Medline, acerca de los elementos protagonistas en la relación entre estrés oxidativo y desequilibrio neuronal que constituyen la base de las afectaciones conductuales en el desarrollo de la adicción y durante la abstinencia. Nuestro objetivo es contribuir a clarificar el conocimiento existente acerca de las relaciones entre determinados factores biológicos (como neurotransmisores e indicadores de desbalance redox) y los efectos del alcohol, poniendo de manifiesto la importancia de algunos factores de riesgo para el desarrollo del alcoholismo.
Referencias
Roerecke M, Rehm J. Alcohol intake revisited: risks and benefits. CurrAtheroscler Rep. 2012; 14: 556-562
2.Roerecke M, Rehm J. Alcohol use disorders and mortality: a systematic review and meta-analysis. Addiction. 2013; 108: 1562-1578 114.
Zeisser C, Stockwell TR, Chikritzhs T, Cherpitel C, Ye Y, Gardner C. A systematic review and meta-analysis of alcohol consumption and injury risk as a function of study design and recall period. Alcohol ClinExp Res. 2013; 37 Suppl 1:E1-E8
Drake MT, Murad MH, Mauck KF, Lane MA, Undavalli C, Elraiyah T, et al. Clinical review. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis. J ClinEndocrinolMetab. 2012; 97: 1861-1870
Azar MM, Springer SA, Meyer JP, Altice FL. A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Drug Alcohol Depend. 2010; 112: 178-193.
Shuper PA, Neuman M, Kanteres F, Baliunas D, Joharchi N, Rehm J. Causal considerations on alcohol and HIV/AIDS--a systematic review. Alcohol Alcohol. 2010; 45: 159-166
Samokhvalov AV, Irving HM, Rehm J. Alcohol consumption as a risk factor for pneumonia: a systematic review and meta-analysis. Epidemiol Infect. 2010; 138: 1789-1795.
Guardia Serecigni, J.. La reducción del consumo de alcohol. Un nuevo objetivo en el tratamiento del alcoholismo de baja gravedad. Adicciones, 2015, 27, 3-7
Rehm J. The Risks Associated With Alcohol Use and Alcoholism. Alcohol Res Health. 2011; 34: 135-143.
Hermens DF, Lagopoulos J, Tobias-Webb J, De RT, Dore G, Juckes L, et al. Pathways to alcohol-induced brain impairment in young people: a review. Cortex. 2013; 49: 3-17.
Espert R, Gadea M. Neurobiología del alcoholismo. Bases bioquímicas y neurobiológicas de la adicción al alcohol. En: Monografíasobre el alcoholismo. Barcelona: Socidrogalcohol; 2012. p. 75-120
Heinz AJ, Beck A, Meyer-Lindenberg A, Sterzer P, Heinz A. Cognitive and neurobiological mechanisms of alcohol-related aggression. Nat Rev Neurosci. 2011; 12: 400-413.
Mattisson C, Bogren M, Ojehagen A, Nordstrom G, Horstmann V. Mortality in alcohol use disorder in the Lundby Community Cohort--a 50 year follow-up. Drug Alcohol Depend. 2011; 118: 141-147.
Alfonso-Loeches S, Guerri C. Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. CritRevClinLabSci. 2011; 48: 19-47
Roerecke M, Rehm J. Alcohol intake revisited: risks and benefits. CurrAtheroscler Rep. 2012; 14: 556-562
Pascual F. Conceptos y diagnóstico del alcoholismo. En: Monografía sobre el alcoholismo. Barcelona: Socidrogalcohol; 2012. p. 121-142. 11.
Climent B, Gago N, Llerena G, González V. Patología médica asociada al consumo perjudicial de alcohol. En: Monografíasobre el alcoholismo. Barcelona: Socidrogalcohol; 2012. p. 181-218.
Ebrahim IO, Shapiro CM, Williams AJ, Fenwick PB. Alcohol and sleep I: effects on normal sleep. Alcohol ClinExp Res. 2013; 37:539-549.
Zaazaa A, Bella AJ, Shamloul R. Drug addiction and sexual dysfunction. EndocrinolMetabClin North Am. 2013; 42: 585-592 24
Li Y, Mao Y, Zhang Y, Cai S, Chen G, Ding Y, et al. Alcohol drinking and upper aerodigestive tract cancer mortality: A systematic review and meta-analysis. Oral Oncol. 2014; 50: 269-275.
. Rehm J, Taylor B, Mohapatra S, Irving HM, Baliunas D, Patra J, et al. Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis. Drug Alcohol Rev. 2010; 29: 437-445
Tramacere I, Negri E, Bagnardi V, Garavello W, Rota M, Scotti L, et al. A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1: overall results and dose-risk relation. Oral Oncol. 2010; 46: 497-503
Roerecke M, Rehm J. Cause-specific mortality risk in alcohol use disorder treatment patients: a systematic review and meta-analysis. Int J Epidemiol. 2014,4:6
Bilello J, McCray V, Davis J, Jackson L, Danos LA. Acute ethanol intoxication and the trauma patient: hemodynamic pitfalls. World J Surg. 2011; 35: 2149-2153
Danielsson AK, Wennberg P, Hibell B, Romelsjo A. Alcohol use, heavy episodic drinking and subsequent problems among adolescents in 23 European countries: does the prevention paradox apply? Addiction. 2012; 107: 71-80
Ridley NJ, Draper B, Withall A. Alcohol-related dementia: an update of the evidence. Alzheimers Res Ther. 2013; 5: 3.
Jelski W, Kutylowska E, Szmitkowski M. The role of ethanol in pathogenesis of pancreatitis. Pol MerkurLekarski. 2011; 30: 66-68.
Jin M, Cai S, Guo J, Zhu Y, Li M, Yu Y, et al. Alcohol drinking and all cancer mortality: a meta-analysis. Ann Oncol. 2013; 24: 807-816.
Pelucchi C, Tramacere I, Boffetta P, Negri E, La Vecchia C. Alcohol consumption and cancer risk. Nutr Cancer. 2011; 63: 983-990.
Cuomo R, Andreozzi P, Zito FP. Alcoholic beverages and carbonated soft drinks: consumption and gastrointestinal cancer risks. Cancer Treat Res. 2014; 159: 97-120.
Varela-Rey M, Woodhoo A, Martinez-Chantar ML, Mato JM, Lu SC. Alcohol, DNA methylation, and cancer. Alcohol Res. 2013; 35: 25-35.
Bay B, Kesmodel US. Prenatal alcohol exposure - a systematic review of the effects on child motor function. ActaObstetGynecol Scand. 2011; 90: 210-226
Hellemans KG, Sliwowska JH, Verma P, Weinberg J. Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders. NeurosciBiobehav Rev. 2010; 34: 791-807.
Brenaut E, Horreau C, Pouplard C, Barnetche T, Paul C, Richard MA, et al. Alcohol consumption and psoriasis: a systematic literature review. J EurAcadDermatolVenereol. 2013; 27 Suppl 3: 30-35
Farkas A, Kemeny L. Alcohol, liver, systemic inflammation and skin: a focus on patients with psoriasis. Skin Pharmacol Physiol. 2013; 26: 119-126.
Downing J, Hughes K, Bellis MA, Calafat A, Juan M, Blay NT. Factors associated with risky sexual behaviour: a comparison of British, Spanish and German holidaymakers to the Balearics. Eur J Public Health. 2011; 21: 275-281.
Guías Clínicas Basadas en la Evidencia Científica. Socidrog alcohol, España, 2007; 15-18.
Rehm JT, Shield KD, Rehm MX, Gmel G, Frick U. Alcohol consumption, alcohol dependence and attributable burden of disease in Europe. Potential gains from effective interventions for alcohol dependence. Toronto: Centre for Addiction and Mental Health (CAMH); 2012. Disponible en: http://amphoraproject.net/w2box/data/AMPHORAReports/CAMH_Alcohol_Report_Europe_2012.pdf
Bye EK, Rossow I. The impact of drinking pattern on alcohol-related violence among adolescents: An international comparative analysis. Drug Alcohol Rev. 2010; 29: 131-137
Siciliano V, Mezzasalma L, Lorenzoni V, Pieroni S, Molinaro S. Evaluation of drinking patterns and their impact on alcohol-related aggression: a national survey of adolescent behaviours. BMC Public Health. 2013; 13: 950.
Roerecke M, Rehm J. Irregular heavy drinking occasions and risk of ischemic heart disease: a systematic review and meta-analysis. Am J Epidemiol. 2010; 171: 633-644
Carnevale R, Nocella C. Alcohol and cardiovascular disease: still unresolved underlying mechanisms. VasculPharmacol. 2012; 57: 69-71.
Pereiro C. Manual de Adicciones para Médicos Especialistas en Formación. Socidrogalcohol. España, 2009; 3494:505-506.
Ridley NJ, Draper B, Withall A. Alcohol-related dementia: an update of the evidence. Alzheimers Res Ther. 2013; 5: 3
Hermens DF, Lagopoulos J, Tobias-Webb J, De RT, Dore G, Juckes L, et al. Pathways to alcohol-induced brain impairment in young people: a review. Cortex. 2013; 49: 3-17.
Campos J, Roca L, Gude F, Gonzalez-Quintela A. Long-term mortality of patients admitted to the hospital with alcohol withdrawal syndrome. Alcohol ClinExp Res. 2011; 35: 1180-118654.
Caputo F, Vignoli T, Leggio L, Addolorato G, Zoli G, Bernardi M. Alcohol use disorders in the elderly: a brief overview from epidemiology to treatment options. ExpGerontol. 2012; 47: 411-416.
Anderson P. The impact of alcohol in health. En: Alcohol in the European Union Consumption, harm and policy approaches. Copenhagen: World Health Organization Regional Office for Europe; 2012.p.5-9.Disponibleen: http://www.euro.who.int/__data/assets/pdf_file/0003/160680/e96457.pdf.
Squeglia LM, Schweinsburg AD, Pulido C, Tapert SF. Adolescent binge drinking linked to abnormal spatial working memory brain activation: differential gender effects. Alcohol ClinExp Res. 2011; 35: 1831-1841.
Koob G. Neurobiology of Addiction. Focus. 2011; Volume 9, Issue 1:55-65
Koob GF, Volkow ND Neurocircuitry of addiction. Neuropsychopharmacology. 2010, 35(1):217-38.
Schuckit, M.A.; Tipp, J.E.; Reich, T.; Hesselbrock, V.M.; AndBucholz, K.K. The histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects. Addiction, 1995, 90:1335–1347.
Finn D, CrabbJ.”Exploring Alcohol Withdrawal Syndrome”. Alcohol Health and Research World, 1997, Vol 21:149:156.
Oviedo H, Arboleda P. “Fisiopatología y Tratamiento del Síndrome de Abstinencia de Alcohol”. Universitas Médica, 2006, Vol 21: 112-120. Pontificia Universidad Javeriana de Barranquilla, Colombia.
Davis M. The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci. 2003 July; 28(4): 263–274
Rengifo A y col Receptores GABA A y dependencia alcohólica,Ingeniería y Ciencia, 2005, Vol1, Núm 1 ,Pág 77-96,)
Vetreno RP, Hall JM, Savage LM. Alcohol-related amnesia and dementia: animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction and cognitive impairment. Neurobiol Learn Mem. 2011; 96: 596-608
Ambrosio, E. y Fernández, E. Fundamentos Neurobiológicos de las Adicciones, Neurociencia y Adicción. 2011. (19-46).
Weafer J, Fillmore MT. Comparison of alcohol impairment of behavioral and attentional inhibition. Drug Alcohol Depend. 2012; 126: 176-182.
S. Waldbaum, M. Patel, Mitochondria, oxidative stress and temporal lobe epilepsy, Epilepsy Res. ,2010; 88: 23–45
F Frías, Torvik A, Torp S. The prevalence of alcoholic cerebrar atrophy. A morphometric and histological study of an autopsy material. J NeurolSci 1986; 75: 4351.
Piazza-Gardner AK, Gaffud TJ, Barry AE. The impact of alcohol on Alzheimer's disease: a systematic review. Aging Ment Health. 2013; 17: 133-146
Guerri C, Pascual M. Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence. Alcohol. 2010; 44: 15-26.
Jacobus J, Tapert SF. Neurotoxic effects of alcohol in adolescence. Annu Rev Clin Psychol. 2013; 9: 703-721
Peeters M, Vollebergh WA, Wiers RW, Field M. Psychological changes and cognitive impairments in adolescent heavy drinkers. Alcohol Alcohol. 2014; 49: 182-186.
Samokhvalov AV, Irving H, Mohapatra S, Rehm J. Alcohol consumption, unprovoked seizures, and epilepsy: a systematic review and meta-analysis. Epilepsia. 2010; 51: 1177-1184.
Briere FN, Rohde P, Seeley JR, Klein D, Lewinsohn PM. Comorbidity between major depression and alcohol use disorder from adolescence to adulthood. Compr Psychiatry. 2013; 55: 526-533
Abernathy K, Chandler LJ, Woodward JJ. Alcohol and the prefrontal cortex. Int Rev Neurobiol. 2010; 91:289-320
. Briere FN, Rohde P, Seeley JR, Klein D, Lewinsohn PM. Comorbidity between major depression and alcohol use disorder from adolescence to adulthood. Compr Psychiatry. 2013; 55: 526-533
PálPacher, Joseph S. Beckman, and Lucas Liaudet Nitric Oxide and Peroxynitrite in Health and Disease Physiol Rev. 2007 January; 87(1): 315–424.
Medici V, Halsted CH. Folate, alcohol, and liver disease. MolNutr Food Res. 2013; 57: 596-606
Cederbaum AI. Alcohol metabolism. Clin Liver Dis. 2012; 16(4):667-85.
Marek E, Kraft WK. Ethanol pharmacokinetics in neonates and infants. CurrTher Res Clin Exp. 2014; 76:90-7.
Elamin EE, Masclee AA, Dekker J, Jonkers DM. Ethanol metabolism and its effects on the intestinal epithelial barrier. Nutr Rev. 2013; 71: 483-499.
Sergio Hernández-Rodríguez1 Estrés oxidativo y nitrosativo como mecanismo de daño al hepatocito producido por el metabolismo del etanol MedIntMéx . 2014; 30:295-308.
Ana Adan y col.. Funciones y potencial terapéutico del óxido nítrico en el sistema nervioso central Prat Psicothema 2005. Vol. 17, nº 2, pp. 275-280
Kwan-Hoon Moon, Bong-Jo Kim, and Byoung J. Song*FEBS Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylationLett. 2005 November 7; 579(27): 6115–6120.
Guo R, Ren J. Alcohol and acetaldehyde in public health: from marvel to menace. Int J Environ Res Public Health. 2010; 7: 1285-1301.
Correa M., Salamone J. D., Segovia K. N., Pardo M., Longoni R., Spina L., et al. Piecing together the puzzle of acetaldehyde as a neuroactive agent. Neurosci. Biobehav. Rev. 36, 404–430 10.1016/j.neubiorev.2011.07.009 [PubMed] [Cross Ref]
García Gutiérrez Marlene, González Ponce Georgina Navarro Soriano Sandra, Cota Escudero Luis Francisco y Olvera Carrillo José Carlos "Estudio sobre los efectos del etanol a nivel de sinapsis neuronal” Episteme. 2006 No. 8-9 Año 2, Octubre-Diciembre
Zimatkin S. M. Histochemical study of aldehyde dehydrogenase in the rat CNS. J. Neurochem. 1991; 56, 1–11
Sun F, Tsuritani I, Honda R, Ma ZY, Yamada Y. Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. Hum Genet. 1999; 105:295-300.
Pérez-Rial S, Ortiz S, Manzanares J. Neurobiología de la dependencia alcohólica Trastornos Adictivos. 2003; 5:4-12.
Crabb DW, Matsumoto M, Chang D, You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. ProcNutr Soc. 2004; 63(1):49-63.
Correa M. Anxiogenic and stress-inducing effects of peripherally administered acetaldehyde in mice: similarities with the disulfiram-ethanol reaction. Pharmacol. Biochem. Behav. 2012; 100, 404–412
Chuck T. L., McLaughlin P. J., Arizzi-LaFrance M. N., Salamone J. D., Correa M. Comparison between multiple behavioral effects of peripheral ethanol administration in rats: sedation, ataxia, and bradykinesia. LifeSci. (2006). 79, 154–161
McLaughlin P. J., Chuck T. L., Arizzi-LaFrance M. N., Salamone J. D., Correa M. Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: effects on lever pressing and response initiation. Pharmacol. Biochem. Behav. 2008; 89, 304–313
Arizzi M. N., Correa M., Betz A. J., Wisniecki A., Salamone J. D. Behavioral effects of intraventricular injections of low doses of ethanol, acetaldehyde, and acetate in rats: studies with low and high rate operant schedules. Behav. Brain Res. 2003; 147, 203–210
Correa M., Arizzi M. N., Betz A., Mingote S., Salamone J. D. Locomotor stimulant effects of intraventricular injections of low doses of ethanol in rats: acute and repeated administration. Psychopharmacology. 2003b; 170, 368–375
Correa M., Arizzi M. N., Salamone J. D. Infusions of acetaldehyde into the arcuate nucleus of the hypothalamus induce motor activity in rats. LifeSci. 2009a; 84, 321–327
Arizzi-LaFrance M. N., Correa M., Aragon C. M., Salamone J. D. Motor stimulant effects of ethanol injected into the substantianigra pars reticulata: importance of catalase-mediated metabolism and the role of acetaldehyde. Neuropsychpharmacology . 2006; 31, 997–1008
McLaughlin P. J., Chuck T. L., Arizzi-LaFrance M. N., Salamone J. D., Correa M. Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: effects on lever pressing and response initiation. Pharmacol. Biochem. Behav. 2000;. 89, 304–313
National Institute on Drug Abuse.). Las drogas, el cerebro y el comportamiento. NIDA La ciencia de la adicción. Departamento de Salud y Servicios Humanos de los Estados Unidos. Publicación NIH. 2014 No. 08-5605.
Kenny PJ Epigenetics, microRNA, and addiction. Dialogues ClinNeurosci. 2014; 16(3):335-44Q,
Vendruscolo LF, Goldman D, Heilig M DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity. J Neurosci. 2015; 35(15):6153-64.
Asevedo E, Mendes AC, Berk M, Brietzke E. Systematic review of N-acetylcysteine in the treatment of addictions. Rev Bras Psiquiatr. 2014; 36(2):168-75.
Guo R y Ren J Alcohol and Acetaldehyde in Public Health: From Marvelto Menace *Int. J. Environ. Res. Public Health 2010, 7, 1285-1301.
Díaz-Soto M. T., Fraga A, Dranguet Vaillant J y col. Ozone Therapy Ameliorates Nervous System Disorders and Oxidative Stress in Patients During Ethanol Withdrawal—A Pilot StudyOzone: Science & Engineering,2012, 34: 432–437
Díaz-Soto M. T., Fraga A, Dranguet Vaillant J y col. Ozone Oxidative Postconditioning Protects Against the Injury Associated with Alcohol Withdrawal Syndromein RatsScience & Engineering, 2012, 34: 425–431.
Organización Mundial de la Salud. http://www.who.int/mediacentre/factsheets/fs349/es/. Consulta: marzo 2018.
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